1. Batterbury SPJ, Palmer L, Reuter T, de Carvalho D do A, Kehi B, Cullen A. Land access and livelihoods in post-conflict Timor-Leste: no magic bullets. International Journal of the Commons. 2015;9(2):619-647. DOI:
Cancer is a disease which brings about a huge sense of terror. It has therefore,been a threat to human beings globally. Many organic and metallo chemotherapeutics arecurrently available in the market for the treatment of different sorts of cancers, but, stillthere is no drug which can curb this disease at late stages completely and worse, most drugsexhibit severe side effects. The choice for cancer treatment seems to be nanodrugs, whichare effective at much lower concentrations and with much less side effects. Nanodrugs arethe magic bullets, designed to be selective for tumor tissue and to act only on cancer cells.Nanodrugs are macromolecules or nanoparticles that function as targeted carrier systems todeliver active anticancer drug exclusively at the site of cancer. The well known anticancerchemotherapeutics cisplatin, carboplatin, 5-fluorouracil, bleomycin, paclitaxel,doxorubicin, vinblastin and topotecan etc., but also novel drugs including nucleic acids andproteins can be incorporated into these delivery systems. Drugs become active only at thesite of cancer cells. A consideration of the unique properties of nanodrugs seems to bringabout a revolution in cancer treatment which is the urgent need of time. The present chapterdescribes the huge diversity of nanodrugs and highlights the few principles of theirmechanisms. Moreover, the superiority of nano anticancer modalities in comparison to theconventional chemotherapeutic anticancer drugs will be discussed. Recent patents in thefield have been discussed under different sections of the chapter. Recent rocketingdevelopments in the field will be introduced and emphasis has been laid on futureperspectives.
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Keywords: Cancer epidemiology, chemotherapeutics, chemotherapy, conventionalanticancer drugs, dendrimers nanodrugs, drug delivery, future perspectives, inorganic material containing nanodrugs, liposomal nanodrugs, magic bullets, mechanism of action of nanodrugs, micellar nanodrugs, nanodrug diversity, nanodrugs, nanotechnology, organic material based nanodrugs, polymericnanodrugs, recent developments, scope of nanodrugs, targeted medical tools.
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Study of the evolution of antibiotic resistance allows us to understand some of the rules that govern the evolution of innovations in bacteria and, by extension, in the rest of living beings. The evolution of resistance is testament to the incredible adaptive ability of bacteria, which normally find not one, but several genetic solutions to survive antibiotics. Therefore, if we want to continue enjoying the enormous benefits of these magic bullets in the future, we must promote the more rational use of antibiotics that will contribute to reducing the selective pressure put on bacterial populations (Figure 4). Finally, the most fascinating element in the subject of this text is probably the fact that during the minutes it took the readers to go through it, all the genetic adaptation mechanisms we have described here will have actually occurred within their own digestive tract, inside some of the approximately thirty billion bacteria inhabiting it.
the topic of this brief article is a tool that can be applied to a variety of problems: The Moore-Penrose Pseudoinverse.While maybe not exactly a magic bullet, it gives us least-squares optimal solutions, and that is under many circumstances the best we can reasonably expect.
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