Orlistat is a white to off-white crystalline powder. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat has no pK within the physiological pH range.
Miss Alli Sets 25 120 33
XENICAL is available for oral administration as a turquoise hard-gelatin capsule. The capsule is imprinted with black. Each capsule contains a pellet formulation consisting of 120 mg of the active ingredient, orlistat, as well as the inactive ingredients microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, and talc. The capsule shell contains gelatin, titanium dioxide, and FD&C Blue No. 2 with black printing ink containing pharmaceutical grade shellac, propylene glycol, strong ammonium solution, potassium hydroxide and black iron oxide.
The patient should be on a nutritionally balanced,reduced-calorie diet that contains approximately 30% of calories from fat. Thedaily intake of fat, carbohydrate, and protein should be distributed over threemain meals. If a meal is occasionally missed or contains no fat, the dose ofXENICAL can be omitted.
Orlistat is a reversible inhibitor of gastrointestinallipases. It exerts its therapeutic activity in the lumen of the stomach andsmall intestine by forming a covalent bond with the active serine residue siteof gastric and pancreatic lipases. The inactivated enzymes are thus unavailableto hydrolyze dietary fat in the form of triglycerides into absorbable freefatty acids and monoglycerides. As undigested triglycerides are not absorbed,the resulting caloric deficit may have a positive effect on weight control.
During his Regency, the new Crown Prince developed the policy of cautious modernization initiated by Menelik II. Also, during this time, he survived the 1918 flu pandemic, having come down with the illness.[73] He secured Ethiopia's admission to the League of Nations in 1923 by promising to eradicate slavery; each emperor since Tewodros II had issued proclamations to halt slavery,[74] but without effect: the internationally scorned practice persisted well into Haile Selassie's reign with an estimated 2 million slaves in Ethiopia in the early 1930s.[75][76]
Upon Zewditu's death, Tafari himself rose to emperor and was proclaimed Neguse Negest ze-'Ityopp'ya, "King of Kings of Ethiopia". He was crowned on 2 November 1930, at Addis Ababa's Cathedral of St. George. The coronation was by all accounts "a most splendid affair",[94] and it was attended by royals and dignitaries from all over the world. Among those in attendance were The Duke of Gloucester (King George V's son), Marshal Louis Franchet d'Espèrey of France, and the Prince of Udine representing King Victor Emmanuel III of Italy. Emissaries from the United States,[95] Egypt, Turkey, Sweden, Belgium, and Japan were also present.[94] British author Evelyn Waugh was also present, penning a contemporary report on the event, and American travel lecturer Burton Holmes shot the only known film footage of the event.[96][97] One newspaper report suggested that the celebration had incurred a cost in excess of $3,000,000.[98] Many of those in attendance received lavish gifts;[99] in one instance, the Christian emperor even sent a gold-encased Bible to an American bishop who had not attended the coronation, but who had dedicated a prayer to the emperor on the day of the coronation.[100]
Ethiopia became the target of renewed Italian imperialist designs in the 1930s. Benito Mussolini's Fascist regime was keen to avenge the military defeats Italy had suffered to Ethiopia in the First Italo-Abyssinian War, and to efface the failed attempt by "liberal" Italy to conquer the country, as epitomised by the defeat at Adwa.[103][104][105] A conquest of Ethiopia could also empower the cause of fascism and embolden its empire's rhetoric.[105] Ethiopia would also provide a bridge between Italy's Eritrean and Italian Somaliland possessions. Ethiopia's position in the League of Nations did not dissuade the Italians from invading in 1935; the "collective security" envisaged by the League proved useless, and a scandal erupted when the Hoare-Laval Pact revealed that Ethiopia's League allies were scheming to appease Italy.[106]
Take care not to spoil the good name of Ethiopia by acts [that] are worthy of the enemy. We shall see that our enemies are disarmed and sent out the same way they came. As Saint George who killed the dragon is the Patron Saint of our army as well as of our allies, let us unite with our allies in everlasting friendship and amity in order to be able to stand against the godless and cruel dragon [that] has newly risen and [that] is oppressing [hu]mankind.[141]
In 1948, the Harari Muslims of Harar with Somali allies staged a significant rebellion against the empire; the state responded violently. Hundreds were arrested and the entire town of Harar was put under house arrest.[148] The government also took control of many assets and estates belonging to the people.[149][150] This led to a massive exodus of Hararis from the Harari Region, which had not occurred in their history prior.[16][151] The dissatisfaction of the Harari stemmed from the fact that they had never received limited autonomy of Harar, which was promised by Menelik II after his conquest of the kingdom. The promise was eroded by successive Amhara governors.[152] According to historians Tim Carmicheal and Roman Loimeier, Haile Selassie was directly involved in the suppression of the Harari movement that formed as a response to the crackdown on Hararis who collaborated with the Italians during their occupation of Ethiopia from 1935 to 1941.[153][154]
While he had fully approved and assured Ethiopia's participation in UN-approved collective security operations, including Korea and Congo, Haile Selassie drew a distinction between it and the non-UN-approved foreign intervention in Indochina, consistently deploring it as needless suffering and calling for the Vietnam War to end on several occasions. At the same time he remained open toward the United States and commended it for making progress with African Americans' Civil Rights legislation in the 1950s and 1960s, while visiting the US several times during these years.
22': Shocking miss from Kane, but he is offside anyway! Croatia make a mistake at the back, and Sterling pounces on it. He passes it to Kane, who missed the target, almost knowingly he was offside.
The Bottomley Case BENCH DISCHARGE DEFENDANTS Mr. Bottomley on Friday resumed his speech for the defence in the case heard at the London Guildhall in which he a.nd three other defendants were charged with conspi- racy. He had been wondering, he said, where the prosecution would have been if ho had net given them permission to investigate hia accounts at his brokers. Without those accounts they could not have traced the alleged duplications. Regarding stock opera- tions, nearly all the witnesses had not only never complained of being defrauded, but they did not even say that they had when in the box. It was a remarkable fact, Mr. Eottomley continued, that when hostilities between the Official Receiver's department and the company commenced one of the charges was, not that they had committed a iraad by palming off worthless paper on sub- scribers, but fraud upon the company itself in depleting its valuable assets by giving subscribers shares at ten shillings which had cost the company a sovereign. Even before they gave subscribers those cash shares they wanted to see it they oould carry through it sale then contemplated, as they were nego- tiating with a company whose shares stood at. a big premium to ta^e them over. There was a draft. agreement of this transaction or; the minutes, and yet this had not been produced. Mr. Bottomley dealt with other matters, among them the alleged destruction of books-, and asked why if statements were fraudulent ether directors were not there with him. Hie Magiseratc told Mr. Bottomley that he held there was no specific evidence as to the ,?d4once as to the destruction of books. After Mr. Bottomley had completed his speech the magistrate retired to his room, and. after about ten minutes' absence, returned to court and announced that he had come to the conclusion that in this case no jury would convict. He, therefore, declined to commit the defendants, and the summonses against Mr. Bottomley and his co-defendants would be dismissed. The decision was received with loud cheer- ing in court. BOTTOMLEY DEFENCE COST 6,000. Mr. Bottomiey, iiiterview-ed after his dis- charge, said he had expected to be free by Tuesday, but was unprepared that morning for so dramatic and sudden a termination of the case. The defence had cost him 6,000. He hoped to resume his Parliamentary duties on Friday next.
United States House of Representatives legislative business on March 9, 1999 with one-minute speeches and debate on the United Nations Human Rights Commission meeting, education funding, and special order speeches. 2ff7e9595c
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